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Infectious Diseases · Acute Intestinal Infections

Salmonellosis

Salmonellosis

Salmonellosis is an acute intestinal infection whose clinical picture notably features the rarely encountered gastritic variant. Diagnosing this form requires careful exclusion of acute somatic and surgical pathologies.

Special FormThe gastritic variant is rare, but presents the greatest diagnostic challenge
Differential DiagnosisRequires the exclusion of appendicitis, cholecystitis, and other "acute" conditions
MaskingCan mimic myocardial infarction
Similar InfectionsMust be differentiated from campylobacteriosis and escherichiosis
2 min readFor medical studentsUpdated 09/24/2026
Material prepared by WhiteCoat Pro editorial team based on platform study guidesReviewed by medical editor: Aulov A. A., general practitioner · 09/24/2026

Gastritic variant of salmonellosis

In infectious disease clinical practice, salmonellosis can manifest in various forms. Doctors exercise particular caution regarding the so-called gastritic variant of the infection.

This form is rare, yet it poses the greatest difficulty during the preliminary diagnosis stage. The leading symptoms in this variant are localized in the upper gastrointestinal tract, requiring the clinician to conduct a broad differential diagnostic search to rule out life-threatening conditions.

Differential diagnosis with surgical pathology

When suspecting the gastritic variant of salmonellosis, it is crucial to promptly rule out acute surgical pathology that requires immediate surgical intervention.

The list of diseases for differential diagnosis includes:

  • Acute appendicitis;
  • Acute cholecystitis;
  • Acute pancreatitis;
  • Mesenteric vessel thrombosis;
  • Ectopic pregnancy (in women of reproductive age).

Misinterpreting "acute abdomen" symptoms as manifestations of an intestinal infection can lead to a fatal delay in surgical treatment.

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Differential diagnosis with somatic and infectious diseases

In addition to acute surgical pathology, the symptoms of the rare gastritic variant of salmonellosis can mimic severe somatic diseases. First and foremost, myocardial infarction must be ruled out, especially in the presence of pronounced pain syndrome in the epigastric region.

Diagnostic workup also includes differentiation from infectious gastroenteritis of other etiologies. This group includes:

  1. Campylobacteriosis;
  2. Escherichiosis;
  3. Yersiniosis;
  4. Shigellosis.

To confirm the etiology of intestinal infections, serological methods based on detecting a rise in specific O-antibody titers in paired sera can be used (blood is drawn in the 1st–2nd weeks and repeatedly in the 3rd–4th weeks of the disease).

Briefly: answers to topical questions

What changes in the coprogram are observed in salmonellosis?

In salmonellosis, the coprogram picture depends on the specific clinical variant of the course; inflammatory changes are variable.

What changes in the complete blood count (CBC) are typical for the acute phase of salmonellosis?

In the complete blood count (CBC) for salmonellosis, neutrophilic leukocytosis with a band shift is possible. In generalized forms of salmonellosis, leukocytosis with preserved eosinophils and lymphopenia are also noted.

Class and exam questions

Which variant of salmonellosis presents the greatest diagnostic difficulty?

The greatest difficulty is presented by the rarely encountered gastritic variant of salmonellosis, as it requires differentiation from acute surgical and somatic pathologies.

With which cardiovascular pathology must the gastritic variant of salmonellosis be differentiated?

First and foremost, myocardial infarction must be ruled out.

Which surgical diseases can present under the mask of the gastritic variant?

These include acute appendicitis, acute cholecystitis, acute pancreatitis, mesenteric vessel thrombosis, and ectopic pregnancy.

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What else to study on this topic

  • Acute surgical diseases of the abdominal organs
  • Differential diagnosis of myocardial infarction (abdominal form)
  • Infectious gastroenteritis: campylobacteriosis and escherichiosis
  • Serological diagnostic methods for intestinal infections (detection of O-antibodies)

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