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Age-related physiology

Physiologia aetatis

Age-related physiology studies the patterns of growth, physical development, and functional changes in the human body from conception to old age. Knowledge of age-related characteristics allows for a proper assessment of health status, reactions to external stimuli, and the stages of maturation of organ systems.

Duration of ontogenesisHuman intrauterine development lasts about 270 days
Infant respirationThe respiratory rate in newborns is about 40 movements per minute
Periods of lifePostnatal ontogenesis includes 12 main age stages
Critical stageThe first 8 weeks of embryonic development are the most vulnerable
3 min readFor medical studentsUpdated 10.10.2026
Material prepared by WhiteCoat Pro editorial team based on platform study guidesPending instructor review

Basic laws of growth and development

The concept of growth implies an increase in total body mass and body dimensions due to an increase in the number and size of cells, as well as the accumulation of non-cellular substance and waste products. Growth can be limited or unlimited.

In turn, physical development combines morphological and functional indicators that determine a person's strength, endurance, and working capacity. An age period is understood as a time interval during which developmental processes and physiological characteristics are identical, and reactions to stimuli are unambiguous.

Stages of prenatal and postnatal ontogenesis

The human life cycle is divided into several global stages:

  1. Progenezis is the period of formation of germ cells (gametes) with a haploid set of chromosomes and their subsequent fusion during fertilization to form a diploid zygote.
  2. Embryonic (prenatal) period is intrauterine development lasting about 270 days. It includes the embryonic period (up to 8 weeks, when all organ systems are laid down) and the fetal period (from the 9th week until birth).
  3. Postembryonic (postnatal) period begins at birth and continues until the end of life, being subdivided into pre-reproductive, reproductive, and post-reproductive stages.

Table of key stages of postnatal development:

PeriodAgeCharacteristic
Newborn periodFirst 10 daysSleeping most of the time
InfancyFrom 11 days to 1 yearActive development, first attempts to sit and walk
Early childhood1–3 yearsConfident walking, mastery of speech
AdolescenceBoys 13–16, girls 12–15 years oldPuberty, restructuring of the neurohumoral system
YouthYoung men 17–21, young women 16–20 years oldOnset of physiological maturity, completion of growth
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Anatomical and physiological characteristics of the respiratory system in children

A child's respiratory organs have a number of important differences from the adult body:

  • Upper respiratory tract: narrow and short nasal passages create a risk of rapid impairment of nasal breathing with minimal rhinitis, which interferes with sucking and sleeping.
  • Lower respiratory tract: bronchioles have a small lumen, so mucosal edema easily leads to bronchoobstruction and atelectasis. Due to the physiological narrowing of the bronchioles upon exhalation, there is a risk of air trapping (hyperinflation).
  • Biomechanics: horizontal arrangement of the ribs and weak respiratory muscles limit the depth of inspiration. Compensation for respiratory failure in infants occurs due to an increased respiratory rate.
  • RR and auscultation: the frequency of respiratory movements in newborns is about 40 per minute with a pulse ratio of 1:4. Normally, puerile breathing is auscultated — enhanced vesicular breathing due to a thin chest wall.
How to memorize

The rule of "four eights": 8 weeks is the most vulnerable embryonic period, and the respiration-to-pulse ratio in infants is 1:4 (like 4 to 16).

Class and exam questions

What is physical development and how does it differ from growth?

Growth is an increase in body mass and dimensions due to cellular and non-cellular structures. Physical development is broader: it is a set of not only morphological but also functional indicators that determine the endurance and working capacity of the organism.

Why can a mild runny nose cause severe respiratory impairment in young children?

In young children, the nasal passages are anatomically very narrow and short. Even minimal mucosal edema during rhinitis significantly hinders nasal breathing, which disrupts the process of sucking and sleeping in infants.

What is the essence of the critical periods of intrauterine development?

These are phases of greatest vulnerability of the embryo and fetus to the action of damaging factors. The first 8 weeks of embryonic development, when active laying down of all organ systems occurs, are recognized as the main critical stage.

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What else to study on this topic

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  • Structural features of the mature follicle and oocyte membranes (zona pellucida and corona radiata)
  • Dynamics of changes in intrapleural pressure and elastic recoil of the lungs with age
  • Perinatal period: antenatal, intranatal, and postnatal stages
  • Particular periodization of sexual development in girls ("neutral" period and menarche)

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