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Physiology · Inhibition of Conditioned Reflex Activity

Conditioned inhibition

Internal, or conditioned inhibition is an active nervous process that occurs directly within the conditioned reflex arc itself. Unlike external reactions, it is not innate and requires special conditions for its development, the main one being the absence of reinforcement.

Main conditionAbsence of reinforcement for a previously established conditioned signal.
Consolidation mechanismFormation of a new action result acceptor in response to non-reinforcement.
SignificanceForms the basis for teaching human behavioral rules and develops self-control.
4 min readFor medical studentsUpdated 09/24/2026
Material prepared by WhiteCoat Pro editorial team based on platform study guidesReviewed by medical editor: Aulov A. A., general practitioner · 09/24/2026

General characteristics and developmental dynamics

Internal inhibition differs fundamentally from external inhibition in that it forms within the reflex arc itself. A simple distraction of attention is not enough for it to occur; the process requires targeted learning.

The dynamics of this state's development pass through two key stages:

  1. Initial stage. When the habitual signal sounds without reinforcement, an orienting-investigatory reaction initially occurs (making the picture externally similar to external inhibition). Later, this reaction transforms into a negative emotion. At first, generating an inhibitory response proceeds with great difficulty; the organism resists altering its stereotype.
  2. Consolidation stage. Over time, the process becomes automated and executes easily. According to the theory of functional systems, the physiological mechanism of this stage consists in forming a new action result acceptor that already "expects" the exact absence of reinforcement.

Extinction and differential inhibition

Depending on the conditions under which reinforcement is withheld, several independent types of internal inhibition are distinguished.

Extinction inhibition Occurs in the classical situation: a previously stable conditioned signal simply ceases to be reinforced by the unconditioned stimulus. If the signal is presented repeatedly without reinforcement, the magnitude of the conditioned response (e.g., salivation) gradually drops to zero. Physiologically, this process is accompanied by distinct changes in the animal's breathing. As P.K. Anokhin noted, such autonomic shifts indicate the development of a profound negative emotion and a so-called "difficult state".

Differential inhibition Develops when it is necessary to train the system to distinguish between similar stimuli. In this case, one conditioned stimulus receives reinforcement, while another very close to it in physical parameters does not. The process proceeds in two phases:

  • Phase of generalization: the animal produces a conditioned response to both stimuli without making a distinction between them.
  • Stage of concentration: the response persists only to the previously reinforced signal and disappears completely for the unreinforced one.

Differentiation is precisely what underlies the training of humans in strict behavioral rules.

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Delayed inhibition and conditioned inhibitor

Delayed inhibition Forms in a situation where reinforcement is not completely cancelled, but significantly postponed (delayed) in time from the onset of the conditioned stimulus. If the delay is, for example, 2–3 minutes, then inhibition actively operates throughout this entire waiting period. As a result, the feeding response does not occur immediately to the sound or light, but strictly by the moment the food is actually delivered. I.P. Pavlov called this phenomenon the "businesslike approach", since the response is precisely timed to the goal. The development of this type of inhibition plays a crucial role in raising children, particularly in developing self-control.

Conditioned inhibitor Represents a specific combination of stimuli. If a conditioned stimulus (A) on its own is stably reinforced, but its simultaneous application with another stimulus (B) is not reinforced, then this second agent (B) turns into a conditioned inhibitor. The main feature of the conditioned inhibitor is its broad generalization. This formed inhibitory agent is capable of effectively blocking any other conditioned reflex activity, regardless of which previously established reflex it is joined with.

Briefly: answers to topical questions

In which structures of the cerebral cortex is the process of internal inhibition primarily localized?

The process of internal inhibition is primarily localized directly within the cortical cells representing the conditioned stimuli. However, according to modern data, inhibition does not affect the structure of the reflex arc itself. It is implemented along the effector pathways forming the components of the reflex. This gives rise to the phenomenon of schizokinesis, where the specific response is inhibited while autonomic components continue to be registered.

Which autonomic parameters, besides respiratory rate, change during the development of extinction inhibition?

In addition to changes in breathing, alterations in heart rate are registered during the inhibition of a specific response. Autonomic components, such as changes in heart rate and breathing, continue to be recorded during the inhibition of a specific response, such as salivation. This phenomenon is called schizokinesis. A distinct change in breathing during extinction inhibition indicates the development of a negative emotion and a "difficult state" in the animal.

How to memorize

For quick memorization of the types of internal inhibition, use the phrase: Smart Doctor Knows For Sure (Extinction, Differential, Delayed, Conditioned Inhibitor).

Class and exam questions

What is the main difference between internal inhibition and external inhibition?

Internal inhibition occurs within the conditioned reflex arc itself and requires mandatory training (development), whereas external inhibition is innate and occurs spontaneously.

What is the "businesslike approach" according to I.P. Pavlov?

This is a term describing the result of establishing delayed inhibition, where the animal's response is strictly timed to the moment of reinforcement delivery, without superfluous activity during the waiting period.

Why does breathing change during extinction inhibition?

The change in breathing is a physiological marker of the development of a negative emotion and a "difficult state" (according to P.K. Anokhin) experienced by the organism due to the absence of expected reinforcement.

What is the essence of the generalization phase in differentiation?

This is the initial stage of developing differential inhibition, at which the animal responds to both stimuli—both the reinforced and the unreinforced ones—without yet distinguishing between them.

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What else to study on this topic

  • Formation of the action result acceptor (according to P.K. Anokhin) during non-reinforcement.
  • Orienting-investigatory reaction at the initial stage of inhibition.
  • The role of delayed inhibition in the formation of higher mental functions in children.
  • Mechanisms of transition from generalization to the stage of concentration of excitation and inhibition.

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