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Neurology · Chapter 27. Neck, back, and limb pain. Vertebrogenic neurological disorders

Lumbosacral vertebrogenic syndromes

Lumbalgia, Lumboischialgia

Lumbosacral vertebrogenic syndromes are a group of conditions presenting with acute or chronic lower back pain that frequently radiates to the legs. This is the most common localization of spinal pain, periodically occurring in 50–80% of the population due to physical exertion or musculoskeletal pathologies.

PrevalenceOccurs in 50–80% of the population
Myofascial factorGluteal and piriformis muscles are frequently involved in lumbosacral radicular syndrome (lumboischialgia)
Vulnerable nerve rootsL5 and S1 levels are most commonly affected
Key differenceIn lumboischialgia, unlike radiculopathy, pain does not reach the foot and toes
4 min readFor medical studentsUpdated Sep 25, 2026
Material prepared by WhiteCoat Pro editorial team based on platform study guidesReviewed by medical editor: Aulov A. A., general practitioner · 09/24/2026

Classification of non-specific back pain

Lower back and sacral pain is divided into several variants depending on the clinical course and the area of radiation:

  • Lumbago (acute lumbar pain). Characterized by sharp, shooting pain in the lower back. The main provoking factor is physical exertion (e.g., lifting heavy objects).
  • Lumbalgia. Subacute or chronic aching pain syndrome. It develops after physical exertion, an awkward movement, hypothermia, and sometimes without apparent causes. The pain worsens with walking, spinal movements, or prolonged positioning in certain postures. During an acute attack, the patient may freeze in an awkward position, as attempting to move provokes increased pain.
  • Lumboischialgia. A pain syndrome where pain is localized in the lower back, buttock, and radiates along the posterolateral surface of the leg. An important differential diagnostic sign: unlike radiculopathy, the pain does not reach the foot and toes. The causes include pathologies of the zygapophysial joints, intervertebral discs, sacroiliac joints, and myofascial syndromes. In the latter variant, the piriformis, iliopsoas, iliocostalis, as well as the gluteus maximus and medius muscles are involved (palpation reveals areas of local tenderness).

Discogenic radiculopathy

Radiculopathy occurs when spinal nerve roots are affected. Clinically, it presents as acute shooting ("stabbing") pain in the lower back and leg, which is significantly more intense than in muscular syndromes.

Characteristic features:

  1. Radiation: pain spreads in a proximal-to-distal direction, reaching the foot and toes (when the lower lumbar and first sacral roots are affected).
  2. Pain provocation: symptoms worsen in the upright position, during spinal movements, sneezing, and when bringing the chin to the sternum.
  3. Neurological deficit: sensory, reflex, and/or motor disturbances are detected within the innervation zone of the affected nerve root.
  4. Symptoms: a positive Lasegue sign, tension in the back and leg muscles are determined. Scoliosis (spinal curvature) is frequently observed, which noticeably decreases in the horizontal position.

Most commonly, L5 and S1 roots are affected, less commonly L4, and extremely rarely the upper lumbar roots.

Test your knowledge on this topicTasks from the Neurology course bank — immediate answers and explanations.

Topical diagnosis of L5 and S1 radiculopathies

The clinical picture makes it possible to precisely determine the level of spinal nerve root lesion.

SignS1 radiculopathyL5 radiculopathy
Pain localizationLower back $\rightarrow$ buttock $\rightarrow$ posterior thigh $\rightarrow$ posterolateral lower leg $\rightarrow$ lateral edge of the foot and lateral toesLower back $\rightarrow$ buttock $\rightarrow$ lateral thigh and lower leg $\rightarrow$ medial edge of the foot and great toe
HypoesthesiaLateral lower leg and lateral toes (less frequently, posterior thigh)Lateral lower leg and great toe
ReflexesAchilles reflex is lostPreserved
Paresis (weakness)Gastrocnemius muscle (sometimes foot flexors/pronation, toe flexors)Extensor hallucis longus (less commonly foot dorsiflexors/pronation)

Briefly: answers to topical questions

What tension signs, besides Lasegue's sign, are detected in lumbosacral radiculopathy?

In lumbosacral radiculopathy, in addition to Lasegue's sign, Wasserman's and Mackiewicz's signs are elicited.

  • Wasserman's sign — appearance of pain along the anterior surface of the thigh and in the groin upon extension of the leg at the hip joint in a patient lying prone.
  • Mackiewicz's sign — pain in the groin area radiating to the anterior surface of the thigh upon maximal flexion of the lower leg in a patient lying prone.

The purpose of these provocative tests is to elicit reactive pain upon tension of the affected nerve.

Which reflex is lost in L4 spinal nerve root lesion?

In L4 spinal nerve root lesion, the knee jerk reflex is lost.

The neurological status in radiculopathy at this level may also reveal the following changes:

  • Sensory disturbances — the area of hypesthesia corresponds to the pain distribution area spreading along the anteromedial surface of the thigh, and also involving areas such as the medial surface of the lower leg and the medial edge of the foot.
  • Motor disturbances — weakness of the quadriceps femoris muscle (m. quadriceps femoris) is possible.

The vastus lateralis and vastus medialis muscles (m. vastus lateralm. vastus medialis) and the tibialis anterior muscle (m. tibialis anterior) also serve as indicator muscles for this root.

How to memorize

For quick memorization of topography: an L5 lesion "hits" the great toe and the inner edge of the foot (reflexes preserved), while an S1 lesion affects the little toe and the outer edge of the foot (Achilles reflex is lost).

Class and exam questions

How to distinguish lumboischialgia from radiculopathy?

In lumboischialgia, pain radiates down the leg but never reaches the foot and toes. In discogenic radiculopathy, pain radiates distally right down to the toes.

Does scoliosis change in discogenic radiculopathy?

Yes, scoliosis arising from pain and muscle tension often significantly decreases when the patient assumes a horizontal position.

What is myofascial syndrome in lumboishialgia?

It manifests as involvement of the gluteus maximus and medius, piriformis, iliocostalis, and iliopsoas muscles. Palpation reveals zones of local tenderness.

Confused about something? Ask the AIThe AI tutor has reviewed the material on "Lumbosacral Vertiginous Syndromes" and will explain it in simple terms.

What else to study on this topic

  • Cervical pain syndromes: cervicalgia, cervicocranialgia, and cervicobrachialgia
  • C6 and C7 cervical radiculopathies
  • Vertebrogenic cervical myelopathy: etiology and clinical stages
  • Scapulohumeral periarthropathy and scalene myofascial syndrome
  • Nonspecific thoracic pain (thoracalgia)

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