Log in
Neurology · Additional Topics

De Quervain's disease

De Quervain's disease / de Quervain's tenosynovitis

de Quervain's disease is a stenosing tenosynovitis characterized by inflammation of the synovial sheaths of the first osteofibrous compartment on the dorsal aspect of the wrist. The condition selectively affects the tendons of the muscles responsible for abduction and extension of the thumb, causing their thickening, neovascularization, and impaired function.

Localization1st dorsal compartment of the wrist (first osteofibrous canal)
Involved musclesAbductor pollicis longus (APL) and extensor pollicis brevis (EPB)
Ultrasound signEchogenic thickening of the sheath and the tendon itself
Blood flowTendon neovascularization on power Doppler mode
Wrist flexorsMostly lie within the carpal tunnel, except for the FCU and FCR
3 min readFor medical studentsUpdated 10.10.2026
Material prepared by WhiteCoat Pro editorial team based on platform study guidesPending instructor review

Anatomy of the wrist joint and tendons

The wrist joint is frequently subject to injuries due to excessive loading (overuse injuries), which can lead to significant impairment of hand function. Tendons in this region are anatomically divided into two main groups: flexors (flexor tendons) and extensors (extensor tendons).

The flexor tendons are predominantly grouped within the carpal tunnel (carpal tunnel). Exceptions to this rule are the tendons of the flexor carpi ulnaris (flexor carpi ulnaris) and flexor carpi radialis (flexor carpi radialis), which pass outside this canal.

The extensor tendons are located dorsally. The extensor retinaculum (retinaculum extensorum) forms six isolated osteofibrous compartments for them. The numbering of these groups at the wrist level always proceeds in a radial-to-ulnar direction (radial-to-ulnar direction).

Six extensor compartments

To reduce tendon friction against dense structures, all six compartments are lined with specialized synovial sheaths. The distribution of tendons by compartments is as follows:

  1. Abductor pollicis longus and extensor pollicis brevis (APL + EPB).
  2. Extensor carpi radialis longus and brevis (ECRL + ECRB).
  3. Extensor pollicis longus (EPL).
  4. Extensor digitorum and extensor indicis (ED + EI).
  5. Extensor digiti minimi (EDM).
  6. Extensor carpi ulnaris (ECU).
Test your knowledge on this topicTasks from the Neurology course bank — immediate answers and explanations.

Pathogenesis of de Quervain's disease

de Quervain's disease (de Quervain's disease) is a stenosing tenosynovitis directly associated with tendinopathy of the first extensor compartment. The disorder selectively affects the tendons of the abductor pollicis longus (abductor pollicis longus) and extensor pollicis brevis (extensor pollicis brevis).

The pathology manifests upon inflammation of the synovial sheaths of the first compartment. This process results in marked tissue thickening, which disrupts normal tendon biomechanics and leads to joint dysfunction.

Ultrasound diagnostics

To visualize de Quervain's disease, it is optimal to use longitudinal grey-scale ultrasound (grey-scale ultrasound) of the first extensor compartment tendons.

The ultrasound image clearly demonstrates the following diagnostic signs:

  • Thickening of the tendon structure itself.
  • Echogenic thickening of the tendon sheath, which directly corresponds to the pattern of stenosing tenosynovitis.
  • Using power Doppler mode reveals accompanying neovascularization of the affected tendon.

Differential diagnosis: ECU tendinopathy

By comparison, sixth extensor compartment tendinopathy affects the extensor carpi ulnaris (ECU) tendon. It most commonly occurs where the tendon passes over the ulnar styloid.

This is a typical localization of tenosynovitis developing in the setting of various inflammatory arthropathies. Prolonged inflammation of this type can eventually lead to erosion of the ulnar styloid process.

How to memorize

To remember the contents of the first extensor compartment, use the abbreviation APL-EPB: Abductor Pollicis Longus and Extensor Pollicis Brevis. These are the two thumb muscles encountered first in the 1st compartment when counting from the radius to the ulna.

Class and exam questions

In what direction are the wrist extensor compartments conventionally numbered?

Extensor compartments are numbered strictly in a radial-to-ulnar direction. The first compartment, affected in de Quervain's disease, is located on the radial side.

Which specific tendons become inflamed in de Quervain's disease?

The inflammation involves the tendons of the first extensor compartment: the abductor pollicis longus (APL) and extensor pollicis brevis (EPB) muscles.

What does power Doppler demonstrate in this condition?

Power Doppler mode allows the detection of concomitant neovascularization—the pathological formation of new blood vessels within the substance of the inflamed tendon.

How does first-compartment tendinopathy differ from sixth-compartment tendinopathy?

First compartment tendinopathy (de Quervain's disease) causes stenosing tenosynovitis of the APL and EPB tendons. Sixth compartment tendinopathy involves the extensor carpi ulnaris (ECU) over the styloid process and frequently occurs in the setting of inflammatory arthropathies, leading to bone erosion.

Something unclear? Ask the AIThe AI tutor has reviewed the material on "De Quervain's disease" and will explain it in simple terms.

What else to study on this topic

  • Stener lesion: rupture of the ulnar collateral ligament of the thumb with stump retraction.
  • Diagnostic imaging of scapholunate ligament tears and assessment of diastasis on fat-suppressed MRI.
  • Digital subtraction arthrography in wrist ligament injuries and contrast leakage.
  • Osteochondritis dissecans of the humeral capitellum and search for loose intra-articular bodies.
  • Insertion tendinopathies of the elbow joint and ultrasound-guided injection therapy.

Master the entire topic in the "Neurology" course

This is a summary. The course covers everything tested in classes and exams.

  • Complete WhiteCoat Pro guide on de Quervain's disease and 907 more pages on the subject
  • Assignments and quizzes after every topic — just like in a colloquium
  • AI tutor answers questions on the topic anytime
  • 32 video lessons for the subject

Prepared by WhiteCoat Pro faculty in accordance with the medical school curriculum. For educational purposes only.