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Hygiene · Chapter 5. Ecological and hygienic problems of population nutrition

Macronutrients

Macronutrients are the basic components of food, which include proteins, fats, and carbohydrates. They form the basis of the human diet and are necessary to maintain vital activity, unlike micronutrients, which are required in negligible doses.

Main componentsProteins, fats, and carbohydrates form the bulk of the food consumed by humans.
Evolution of the dietSugar consumption in the modern post-industrial era has increased 20-fold.
Loss of enzymesDuring evolutionary development, humans lost some important enzyme systems.
Exogenous regulationBioactive substances from plant foods directly control metabolism.
5 min readFor medical studentsUpdated Sep 25, 2026
Material prepared by WhiteCoat Pro editorial team based on platform study guidesReviewed by medical editor: Aulov A. A., general practitioner · 09/24/2026

Macronutrients and micronutrients: the issue of adequacy

The basis of any diet is macronutrients, which are the fundamental components of food (proteins, fats, and carbohydrates). They constitute the baseline volume of the food we consume.

In contrast, there are micronutrients, which include vitamins, various mineral salts, and other specific substances. Their key functions in the body are plastic and regulatory. The main feature of micronutrients is that the daily requirement for them is measured in negligible amounts: milligrams, micrograms, or special international units (IU).

A serious problem regarding the body's supply arises here. Due to the extremely low concentration of micronutrients in standard food products, a person needs to assimilate a colossal volume of food to obtain an adequate dose. The consequence of this problem is obvious: it is necessary to know precisely which specific foods are rich sources of these substances and purposefully include them in your daily diet.

Nutrient essentiality and exogenous regulation

The concept of nutrient essentiality (indispensability) directly reflects the historical nutritional status of our ancestors. Their diet consisted of extremely diverse plant foods, which served as a rich source of biologically active substances. Such substances include:

  • Glycosides;
  • Alkaloids;
  • Phenolic compounds;
  • Biogenic amines.

The main mechanism of their action is that they provide exogenous regulation of metabolic processes in the body. Upon entering with food, these compounds are able to interact with cells in two ways: either directly or after prior activation by corresponding enzymes.

Test your knowledge on the topicTasks from the Hygiene course question bank — answer and detailed explanation provided immediately.

Nutrition evolution and pathogenesis of alimentary problems

In the process of long evolution, human lifestyle and dietary patterns underwent significant changes. One of the most important consequences of this transformation was the loss of certain enzyme systems by the human body.

The pathogenesis of modern alimentary (nutrition-related) problems lies in a historical dissonance. On the one hand, food is precisely what evolutionarily shaped humans. On the other hand, the metabolic imbalance observed today is a direct consequence of human activity itself, namely, a radical change in the structure of human nutrition.

Dynamics of dietary structure depending on lifestyle

Analysis of various historical periods clearly demonstrates a drastic change in the human diet in the modern era. Statistics show that currently, the consumption of animal fats has more than doubled, and sugar consumption has increased twentyfold.

Human lifestyle and dietary structure (according to V.A. Tutelyan, 1998)

Development periodFats, gSugar, gStarch, gProtein, gSalt, gFiber, g
Pre-agricultural15–20050–7015–20140
Post-agricultural10–15560–7510–155–1560–120
Post-industrial402025–30121020

In the pre-agricultural period, the diet was characterized by a complete absence of sugar. Fat and protein consumption was at the level of 15–20 grams. The basis consisted of starch (50–70 grams) and fiber (40 grams), with minimal salt consumption—only 1 gram.

With the transition to the post-agricultural period, sugar appeared in the diet (5 grams), while the proportion of fiber (up to 60–120 grams) and starch (60–75 grams) significantly increased. Salt consumption increased to 5–15 grams, whereas the amount of fats and proteins slightly decreased (to 10–15 grams).

The post-industrial period demonstrates a radical shift. Fat consumption reached 40 grams, and sugar reached 20 grams. At the same time, the amount of starch dropped sharply (to 25–30 grams) and fiber (to 20 grams). Protein levels were 12 grams, and salt was 10 grams.

Briefly: answers to topical questions

Which classes of substances belong to micronutrients?

Micronutrients include vitamins, mineral salts, and other substances. Sources cite vitamins, iodine, zinc, selenium, iron, copper, sodium, potassium, calcium, phosphorus, and magnesium as examples. Micronutrients as part of dietary supplements also include lipids, polysaccharides, and vitamins.

What is the modern physiological norm of daily protein, fat, and carbohydrate intake for an adult?

According to regulations, the average daily physiological requirement for an adult is:

  • Proteins — 75 g. Sources also indicate an absolute daily requirement of 80–120 g and an animal protein proportion of 55%.
  • Fats — 83 g, including 25 g of saturated and 11 g of polyunsaturated fatty acids.
  • Carbohydrates — 365 g of digestible carbohydrates.

Which diet-related diseases occur due to macronutrient imbalance?

Macronutrient imbalance and overnutrition can lead to the development of:

  • Obesity — with an excess of energy and carbohydrates.
  • Diabetes mellitus — with an excess of carbohydrates.
  • Gout — with an excess of protein.
  • Atherosclerosis and coronary artery disease — with an excess of fats and lipids.
  • Atherosclerosis — with regular excessive protein intake.
  • Allergization of the body — with an excess of animal protein.

What is the energy value of one gram of proteins, fats, and carbohydrates?

The physiological energy value (caloric coefficient) of one gram of major macronutrients varies depending on their chemical nature.

MacronutrientEnergy value (kcal/g)
Fats9,3
Proteins4,1
Carbohydrates4,1

When oxidized in the body, fats release the greatest amount of energy, whereas proteins and carbohydrates have the same, albeit lower, caloric coefficient.

How to memorize

Macronutrients form the basis of the diet (proteins, fats, carbohydrates). Micronutrients are regulators (vitamins, minerals) whose requirement is measured only in milligrams.

Class and exam questions

What belongs to macronutrients?

Macronutrients include the main components of food: proteins, fats, and carbohydrates. They form the basis of the diet and are consumed in significant amounts.

What is the problem regarding micronutrient sufficiency?

Their content in foods is extremely low. To obtain the required dose (milligrams or micrograms), one must consume a huge volume of food, which is why it is important to purposefully choose source foods.

How has sugar and fat consumption changed in the modern era?

Compared to historical periods, in post-industrial society the consumption of animal fats has increased more than 2-fold, and sugar — by 20 times.

Why does modern man suffer from metabolic imbalance?

This is a direct consequence of changes in the dietary pattern. In the course of evolution, we have lost some enzyme systems, and the modern diet differs radically from the plant-based food of our ancestors.

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What else to study on this topic

  • Plastic and regulatory functions of micronutrients
  • Mechanisms of exogenous regulation of metabolic processes
  • The role of glycosides, alkaloids, and phenolic compounds in nutrition
  • Pathogenesis of diet-related diseases in post-industrial society
  • The impact of fiber deficiency on modern metabolic imbalance

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