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Biology · The Cell — The Elementary Unit of Life

Eukaryotes

*Eukaryota*

A eukaryotic cell is an evolutionarily derived, open biological system capable of self-regulation and self-replication. It invariably consists of a nucleus and cytoplasm, and is bounded externally by a semipermeable membrane.

SystemAn open biosystem involved in the exchange of matter and energy.
BasisBiopolymers (proteins and nucleic acids) and their complexes.
MembraneContains phospholipids, proteins, cholesterol, and the glycocalyx.
3 min readFor medical studentsUpdated 09/24/2026
Material prepared by WhiteCoat Pro editorial team based on platform study guidesReviewed by medical editor: Aulov A. A., general practitioner · 09/24/2026

Fundamental properties of the eukaryotic cell

The cell is a clearly structured system. It is based on essential biopolymers—proteins and nucleic acids—as well as their macromolecular complexes.

As an open system, the eukaryotic cell actively participates in a unified set of metabolic and energy processes. This ensures the maintenance of viability and the reproduction of the biological system as a whole.

Basic components and forms of existence

Any eukaryotic cell includes three main structural blocks:

  1. The cell surface apparatus—separates the internal environment from the external one.
  2. The cytoplasm—the internal contents.
  3. The nucleus—the most important distinguishing feature of eukaryotes.

In nature, eukaryotic organisms exist in two main forms:

  • As an independent unicellular organism.
  • As part of a multicellular organism, where specialized cells combine to form various tissues.
Test your knowledge on the topicTasks from the "Biology" course bank — immediate answers and explanations.

Structure of the surface apparatus and membrane

The surface apparatus is represented by a complex and functionally active membrane.

In the extracellular environment (outside the membrane) lies the glycocalyx, a specific supramembranous complex consisting of carbohydrate components. Carbohydrate chains linked to lipids and proteins—glycolipids and glycoproteins—are also located here.

The membrane itself has a complex composition:

  • Phospholipids and glycolipids form the basis of the membrane framework.
  • Proteins are divided into transmembrane (spanning the membrane completely) and surface or peripheral (adjoining on one side).
  • Cholesterol molecules are located between the hydrophobic tails of lipids. The main function of cholesterol is to regulate the fluidity of the cell membrane.

On the cytoplasmic side, microtubules, which are essential elements of the cell cytoskeleton, adjoin the membrane from the inside.

Briefly: answers to topical questions

What are the fundamental differences between a eukaryotic cell and a prokaryotic cell?

The fundamental differences between a eukaryotic cell and a prokaryotic cell relate to the organization of the genetic apparatus and the processes of realizing hereditary information.

CharacteristicProkaryotesEukaryotes
Distinct nucleusAbsent; DNA is located in the nucleoid region of the cytoplasmPresent; DNA-containing structures are separated from the cytoplasm by the nuclear envelope
Genetic materialCircular DNA, freely located in the cytoplasm; histone proteins are absentLinear double-stranded DNA molecules in the chromosomes of the nucleus; DNA is associated with histone proteins and RNA; chromatin forms chromosomes
Volume of genetic informationSmall; volume up to 1.5 thousand genesLarger; the amount of DNA in eukaryotic nuclei is thousands of times greater than that in bacterial nucleoids; from 5 to 200 thousand genes
Gene structureExons onlyExons and introns
Primary transcriptDirectly functions as mRNARequires processing: intron removal, 5'-cap, poly-A tail; maturation involves processing and splicing
Transcription and translationOccur in the cytoplasm; translation begins before transcription is completedTranscription occurs in the nucleus, translation in the cytoplasm strictly after mRNA exits the nucleus; the processes are separated by the nuclear envelope
PlasmidsPresentAbsent
NucleoliAbsentPresent

Regarding replication, sources indicate that in eukaryotes, unlike prokaryotes, it begins simultaneously at multiple points; a large number of ARS elements are present in eukaryotic chromosomes.

Which organelles are constantly present in the cytoplasm of a eukaryotic cell?

General-purpose organelles are constantly present in the cytoplasm of a eukaryotic cell.

  • Endoplasmic reticulum—a system of cisternae, vacuoles, and tubules.
  • Golgi apparatus—stacks of flat cisternae with budding vesicles.
  • Mitochondria—have two membranes; the inner membrane forms infoldings called cristae.
  • Ribosomes.
  • Lysosomes—vesicles containing hydrolytic enzymes.
  • Cell center (centrosome).
  • Plastids—in plant cells.
How to memorize

To memorize the main membrane components, use the abbreviation PBCC: Phospholipids, Proteins (integral and peripheral), Cholesterol, Glycolipids.

Class and exam questions

What is the fundamental difference in a eukaryotic cell?

It invariably has a distinct nucleus and cytoplasm, and is bounded by a semipermeable membrane.

What is the function of cholesterol in the membrane?

Cholesterol molecules are located between the lipid tails and are responsible for regulating the fluidity of the cell membrane.

What is the glycocalyx?

This is a supramembranous complex in the extracellular environment that consists predominantly of carbohydrate components.

Where are microtubules located relative to the membrane?

Microtubules, as elements of the cytoskeleton, abut the cell membrane from the inside, on the cytoplasmic side.

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What else to study on this topic

  • Self-regulation mechanisms of the eukaryotic cell
  • Cell self-replication processes
  • Detailed structure of transmembrane and peripheral proteins
  • Metabolic and energy processes in the cell
  • Functions of microtubules as part of the cytoskeleton

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