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Pathological anatomy

Chapter 20. Diseases of the Female Genital Organs and Mammary Glands

5 topics with brief reviews: definitions, key facts, and class questions.

This chapter covers the morphological pattern of diseases that determine female reproductive health. We will examine how inflammatory diseases of the female genital organs develop and what irreversible structural alterations they lead to at the tissue level.

Special attention is paid to dyshormonal diseases of the uterus and mammary glands (including endometriosis and mastopathy), as well as a wide spectrum of tumors of the female genital organs. A separate, complex block is dedicated to pregnancy-related pathology and insidious trophoblastic diseases. The concluding focus of the section is breast cancer, its histological variants and molecular subtypes.

In practical classes and exams, the microscopic differences between cervical and endometrial cancer, the morphology of hydatidiform mole and choriocarcinoma, and prognostic factors in breast cancer are tested most rigorously. Pay special attention to modern histological classifications—they are of critical clinical importance in this topic.

Section Topics

Frequently asked questions for this section

How to distinguish cellular or mitotically active leiomyoma from leiomyosarcoma?

In benign leiomyomas, despite high cell density or the presence of 5–9 mitoses, signs of cellular atypia, atypical mitoses, and foci of coagulative necrosis are completely absent.

What is the difference between menorrhagia and metrorrhagia?

Menorrhagia is pathologically heavy bleeding during menstruation. Metrorrhagia is uterine bleeding that is unrelated to the menstrual cycle.

How is adenomyosis classified according to the depth of involvement?

Three degrees are distinguished: in the first, only the submucosal part of the myometrium is affected; in the second, the process reaches the middle of the muscular layer; and in the third, the entire thickness of the uterine wall is involved in the pathological process.

What is the main microscopic difference in the ovaries in PCOS?

Multiple cystic atretic follicles are found in the cortical layer, while corpora lutea and corpora albicantia are completely absent.

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