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Physiology

Sleep

11 topics with brief reviews: definitions, key facts, and class questions.

Sleep is not merely the turning off of consciousness for rest, but an active and complexly organized physiological process critical for memory consolidation and central nervous system recovery. In this section, we analyze in detail the objective signs of sleep, changes in higher nervous activity (HNA), and the physiological significance of this state.

The material covers the evolution of views on the nature of sleep: from historical theories (humoral and vascular) to modern neurophysiological and neurochemical concepts. You will study central mechanisms (cortical and subcortical), sensory and brainstem regulators, as well as complex cortico-subcortical interactions ensuring the alternation of the sleep-wake cycle. A separate block is dedicated to sleep disorders that you will encounter repeatedly in clinical practice.

What is most frequently asked in class? First of all, EEG rhythms during sleep and the differences between slow-wave and paradoxical (REM) sleep. Instructors will certainly require you to detail the structure of the sleep cycle, the nature of dreams, and the role of various neurotransmitters in phase transitions. Pay special attention to neurophysiological mechanisms — these are classic exam questions that require a clear understanding of CNS anatomy and physiology.

Section Topics

Frequently asked questions for this section

What is the traditional theory of the biological significance of sleep?

Historically, sleep was perceived solely as passive rest necessary for restoring the energy reserves of brain cells after active wakefulness. Physiologists even compared this process to the anabiosis of protozoa, when metabolism slows down for survival.

In which phase of sleep does somnambulism (sleepwalking) most frequently occur?

Somnambulism is a motor reaction characteristic exclusively of the slow-wave phase of sleep.

In which stage of sleep is it most difficult to wake a person up?

During the delta wave stage (delta sleep). The arousal threshold at this moment is maximal; very strong auditory stimuli or mechanical impact are required.

Why is paradoxical sleep called REM sleep?

The abbreviation REM stands for Rapid Eye Movement. This is due to the fact that rapid eye movements of the sleeper are observed precisely during this EEG stage.

Is it true that not everyone dreams?

Dreams are seen by absolutely all healthy people. The assertion that some people do not dream is due to the fact that these individuals wake up in the slow-wave sleep phase, which completely "erases" the memory of the dream.

What is the weakness of Angelo Mosso's vascular theory?

The inability to distinguish cause from effect. The outflow of blood from the head to the legs does occur when falling asleep, but it is an accompanying change in vascular tone, not the root cause of cerebral cortex inhibition.

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