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Neurology

Chapter 3. Syndromes of Spinal Cord, Nerve Root, Peripheral Nerve, and Nerve Plexus Lesions

2 topics with a brief review: definitions, key facts, and seminar questions.

Welcome to one of the most important chapters in topical diagnosis. Here we analyze how impulse conduction is impaired, ranging from the spinal cord level down to the distal branches of peripheral nerves.

This section consists of two comprehensive modules. The first is dedicated to spinal cord lesion syndromes at various levels across the transverse and longitudinal axes, including segmental and tract disorders. The second module covers peripheral nervous system lesion syndromes: the clinical presentation of root, nerve plexus, and individual peripheral nerve involvement.

During practical classes and examinations, examiners are strictest on Brown-Séquard syndrome, the differential diagnosis of anterior horn versus peripheral nerve lesions, and the innervation zones of the brachial plexus (wrist drop, claw hand, and ape hand). The ability to logically deduce the lesion focus from these symptoms is a core skill in any clinician's arsenal.

Section Topics

Frequently asked questions for this section

Why is the level of sensory loss located lower than the lesion itself in lateral funiculus involvement?

This is due to the anatomy of the spinothalamic tract. Its fibers cross to the opposite side not strictly horizontally, but ascending obliquely upward, which is why the boundary of sensory disturbances is detected 2–3 dermatomes below the actual lesion level.

How to differentiate a conus medullaris lesion from an epiconus lesion of the spinal cord?

In lesions of the conus medullaris (S~III~), there is no lower limb paresis, and knee and Achilles reflexes are preserved. In lesions of the epiconus (L~IV~ – S~II~), partial lower limb paresis develops and Achilles reflexes are absent.

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