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Neurology

Chapter 29. Facial Pain

6 topics with concise breakdowns: definitions, key facts, and class questions.

Facial pain (prosopalgia) is one of the most challenging interdisciplinary problems in neurology. In this chapter, we discuss the main causes of pain syndromes in the facial region, their pathogenesis, clinical presentation, and therapeutic approaches.

This section covers classic neuropathic syndromes—trigeminal and glossopharyngeal neuralgia, as well as biomechanical pathologies such as temporomandibular joint (TMJ) dysfunction. Special attention is paid to a diagnosis of exclusion that even experienced clinicians struggle with: atypical facial pain.

During practical classes and exams, the differential diagnosis between trigeminal neuralgia and dental pathology is most frequently asked. Be sure to memorize the localization of trigger zones, the difference between neuralgia and neuropathy, and the first-line drugs of choice. Atypical prosopalgia is particularly insidious: the ability to justify this diagnosis will immediately demonstrate the depth of your knowledge to the instructor.

Section Topics

Frequently asked questions for this section

CT or MRI of the head and neck is ordered to rule out secondary structural causes: brain tumors, arteriovenous malformations, and foci of demyelination.

CT or MRI of the head and neck is ordered to rule out secondary structural causes: brain tumors, arteriovenous malformations, and foci of demyelination.

Why do patients with trigeminal neuralgia wrap their faces in scarves even in warm weather?

This is a classic manifestation of avoidance behavior. Patients are panicked that the slightest draft or light breeze will provoke irritation of trigger zones on the face and trigger an excruciating pain attack.

At what age do the first symptoms typically appear?

The disease most frequently debuts in middle-aged and elderly individuals, with the mean age of onset being around 50 years.

Why is TMJ dysfunction often referred to as myofascial syndrome?

Because the pathogenetic basis of the disease in many cases is chronic muscle spasm, particularly in the lateral pterygoid and other masticatory muscles.

Why is a psychiatric consultation mandatory in atypical facial pain?

This is due to the fact that psychiatric pathologies—such as masked depression, schizophrenia, or somatoform disorders—most frequently lie hidden behind this syndrome.

Why perform an MRI when the clinical picture of neuralgia is typical?

To rule out a secondary (symptomatic) nature of the pain, such as a cerebellopontine angle tumor or multiple sclerosis.

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