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Histology

Cytoplasm

13 topics with concise reviews: definitions, key facts, and class questions.

Cytoplasm is the internal content of the cell where all key metabolic processes take place. In this section, we will analyze its chemical basis, inconstant components (inclusions), and specialized cell structures (organelles).

You will study the operation of the synthetic membrane apparatus (ribosomes, smooth and rough endoplasmic reticulum, Golgi apparatus) and the fundamental principles of protein folding. We will examine the power plants of the cell—mitochondria—in detail, as well as the cell digestion and detoxification system: lysosomes and peroxisosomes. Special attention is paid to the cell center and organelles of movement, which ensure the dynamics of the cytoskeleton and cell division.

In practical classes and exams, instructors are most strict about the working principle of the "membrane conveyor" (from synthesis on ribosomes to packaging in the Golgi apparatus), marker enzymes of organelles, and the ability to recognize the ultramicroscopic structure of mitochondria and the ER on electron micrographs. Understanding these structures is the foundation for successfully passing cytology.

Section Topics

Frequently asked questions for this section

Is the hyaloplasm completely structureless?

No. Visually it does indeed seem like a structureless substance, but in reality, its macromolecules are capable of self-assembly and form complex supramolecular complexes.

Why cannot carbohydrate stores in muscles raise blood sugar levels?

Muscle fibers lack the enzyme glucose-6-phosphatase. As a result, glucose-6-phosphate formed during glycogen breakdown cannot be converted into free glucose and pass through the membrane into the bloodstream.

What is the main difference between mitochondria and elements of the vacuolar system?

Mitochondria stand apart because they have two membranes, the inner of which forms infoldings called cristae. Organelles of the vacuolar system have only one membrane.

Why is the granular ER called rough?

Because ribosomes are located on its membrane facing the hyaloplasm, giving it a characteristic rough or granular appearance on electron micrographs.

What is a dictyosome?

This is a structural unit of the Golgi apparatus, representing a stack of 5–10 parallel flat membrane cisternae surrounded by transport vesicles.

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