Read the official guideline · Checked for a newer edition on 2026-10-20
We do not reproduce the guideline text — this page is an independent summary.
Who it applies to
Adults with elevated blood pressure or hypertension managed in primary care, specialist, and hospital settings.
Key recommendations
- Blood pressure should be classified into three categories: non-elevated, elevated blood pressure, and hypertension, based on confirmed office and out-of-office readings.
- Out-of-office blood pressure measurement, using home or ambulatory monitoring, is recommended to confirm the diagnosis of hypertension whenever feasible.
- A standardized blood pressure target of around 120-129 mmHg systolic is recommended for most treated adults, provided treatment is well tolerated.
- Initiation of antihypertensive drug treatment is recommended for patients with confirmed hypertension, and should be considered in elevated blood pressure when cardiovascular risk is high.
- Lifestyle interventions including sodium reduction, weight management, physical activity, and limiting alcohol are recommended at all blood pressure categories.
- Initial combination therapy with two antihypertensive drugs, usually a renin-angiotensin system blocker plus a calcium channel blocker or diuretic, is preferred over starting with monotherapy in most patients.
- Single-pill combinations are recommended to improve adherence to long-term antihypertensive therapy.
- Cardiovascular risk assessment should incorporate total risk estimation rather than blood pressure values alone when deciding on treatment intensity.
- Device-based therapies such as renal denervation may be considered in selected patients with resistant hypertension after specialist evaluation.
- Screening for secondary causes of hypertension is recommended in patients with resistant hypertension or suggestive clinical features, particularly younger patients.
What is new in this edition
- Introduction of the elevated blood pressure category between normal and hypertension
- Lower, more uniform systolic blood pressure target of approximately 120-129 mmHg for most patients
- Stronger emphasis on initial combination drug therapy rather than stepwise monotherapy
- Greater emphasis on out-of-office blood pressure measurement for diagnosis
- Expanded discussion of renal denervation as a treatment option in resistant hypertension
Practice points for students
- Remember the three-tier classification: non-elevated, elevated blood pressure, and hypertension, rather than the older two-tier normal/hypertension split.
- Confirm diagnosis with home or ambulatory monitoring rather than relying on a single office reading.
- Most patients now start on two drugs together rather than one, to reach target faster.
- The default target is lower than many trainees expect, around 120-129 mmHg systolic if tolerated.
- Always consider secondary causes in young patients or those with resistant hypertension.
Condition
Other guidelines on this topic
- 2026 ISH guidelines for the management of hypertension in Africa: the International Society of Hypertension (ISH) African Regional Advisory Group and the Pan African Society of Cardiology (PASCAR)ESH2026Official guideline
- Hypertension in adults: diagnosis and management (NG136)NICE2026Official guideline
- 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice GuidelinesAHA/ACC2025Summary
- Nocturnal blood pressure: pathophysiology, measurement and clinical implications. Position paper of the European Society of HypertensionESH2025Full text
- Hypertension Pharmacological Treatment in Adults: A World Health Organization Guideline Executive SummaryWHO2022Full text
- Management of hypertension and renin-angiotensin-aldosterone system blockade in adults with diabetic kidney disease: Association of British Clinical Diabetologists and the Renal Association UK guideline update 2021ABCD/RA2022Full text
Independent educational summary written by the WhiteCoat Pro editorial team with AI assistance and checked by a second AI model. It does not reproduce the guideline text, tables or figures, and it is not affiliated with or endorsed by ESC. It is not medical advice: always read the original guideline before applying it to patients.