USMLE Step 1 practice questions
Step 1 of the United States Medical Licensing Examination tests the basic sciences that underlie clinical practice: mechanisms, pathology, pharmacology and microbiology, almost always through a clinical vignette. It has been scored pass/fail since January 2022. Below: 49 original practice questions in its style, grouped by topic, each with the answer and an explanation.
Questions by topic
Frequently asked questions
What does USMLE Step 1 test?
Step 1 of the United States Medical Licensing Examination tests the basic sciences that underlie clinical practice: mechanisms, pathology, pharmacology and microbiology, almost always through a clinical vignette. It has been scored pass/fail since January 2022.
Are these official USMLE Step 1 questions?
No. Official exam items are confidential. These are original questions written in the style of USMLE Step 1 for its content outline and checked by an independent model that solves each one blind.
How many questions are free?
All 49 questions in this bank, with answers and explanations, are free and need no account.
USMLE Step 1 is administered by NBME and FSMB. WhiteCoat Pro is not affiliated with or endorsed by them. All questions are original practice items written by the WhiteCoat Pro editorial team with AI assistance and checked by a second, independent AI model that solves every question blind; items with a disputed key are removed. They are not real exam questions. Educational use only, not medical advice.