APSIC guidelines for the prevention of surgical site infections

Pre-operative bath

It is generally accepted that preoperative bathing with soap (antimicrobial or non-antimicrobial) is beneficial prior to surgery, despite the lack of study comparing preoperative bath versus no-preoperative bath on the occurrence of SSIs.

Although recommendations on preoperative bathing in relation to time of administration and the most effective protocol for perioperative bath remains an unresolved issue, it is advisable to take at least 2 baths pre-operatively [4]. Countries with high incidence of multidrug resistant organisms may want to consider the use of an antiseptic instead of plain soap as a preoperative bath. In some Asian countries where allergy to chlorhexidine (CHG) is common or CHG is not available, alternative agents such as octenidine may be used.

1. It is necessary for patients who will undergo surgery to have at least 1 preoperative bath with soap (antimicrobial or non-antimicrobial). (IIB)

Mechanical bowel preparation (MBP) and oral antibiotics for elective colorectal surgery in adults

Oral antibiotics have been used to decrease the luminal bacterial load since the 1930s, but it does not decrease SSI. Similarly, oral or intravenous antibiotics alone showed suboptimal effects. A 2014 Cochrane review also recommended that antibiotics should be administered both orally with mechanical bowel preparation and intravenously in 1 h before surgery to reduce SSIs [5].

1. Combination mechanical bowel preparation and oral antibiotic preparation are recommended for all elective colorectal surgery in adults. (IA)

Hair removal

There are several methods to remove hair at the surgical site preoperatively. Hair removal by shaving and the night before an operation is associated with and increased risk of SSI. Shaving and/or clipping can cause microscopic cuts in the skin that later serve as foci for bacterial multiplication [6, 7].

1. Hair removal should be avoided unless hair interferes with the operative procedure. (IIIB).

2. If hair removal is necessary, a razor should be avoided and an electric clipper should be used. (IA).

3. No recommendation regarding the timing of hair removal by clipper is made. (IIIC).

Methicillin-resistant Staphylococcus aureus (MRSA) screening and decolonization

It is well recognized that MRSA colonization is associated with worse outcomes and a higher risk for both MRSA SSI and overall SSl. The use of MRSA bundle comprising of screening, decolonization, contact precautions, and vancomycin-containing antibiotic prophylaxis was associated with decreased rates of SSI where there was high compliance with the bundle strategies [8–10].

1. Hospitals should evaluate their SSI, Staphylococcus aureus (S. aureus) and MRSA rates, and mupirocin resistant rate, if available, to determine whether implementation of a screening program is appropriate. (IIB)
2. Patients undergoing cardiothoracic and orthopedic surgery with known nasal carriage of S. aureus should receive perioperative intranasal application of mupirocin 2% ointment with or without a combination of CHG body wash. (IA)

Surgical hand/forearm preparation

The objective of cleaning hands and forearms prior to surgery is to reduce the bioburden of bacteria on the skin of the surgical team. The second objective is to inhibit the growth of bacteria. Hands and forearms should undergo a surgical scrub with a surgical antiseptic. When using alcohol-based hand rub (ABHR) solutions containing 60–80% alcohol is recommended. Water quality may be compromised with the use of tap aerators where these are known to be easily colonized with non-fermentative Gram-negative bacteria e.g. Pseudomonas aeruginosa, Acinetobacter baumannii, etc. Hence, where there are issues with the quality of water used in rinsing hands after hand scrubbing, hand rubbing with ABHR agent is a suitable alternative [11–13].

1. Surgical hand preparation is to be performed either by scrubbing with a suitable antiseptic soap and water or a suitable ABHR before donning sterile gown and gloves. (IA)
2. ABHR used in surgical hand preparation should comply with EN 12791 or ASTM E-1115 standards. (IIIA)
3. Where the quality of water used is not assured, surgical hand rub with ABHR is recommended. (IIIB)

Skin antiseptic

Current evidence suggested that alcohol-based preparations are more effective in reducing SSI than aqueous preparations, and should be used, unless contraindicated [14, 15]. Alcohol has a rapid bactericidal effect, albeit with the lack of persistent antibacterial effect. The benefit of iodine or chlorhexidine and alcohol solutions is prolonged bactericidal activity [16].

1. Alcohol based skin antiseptic preparations should be used, unless contraindicated. (IA)

Surgical prophylaxis

Current guidelines suggest the use of narrow spectrum antibiotics, such as cefazolin for most surgical procedures, or cefoxitin for abdominal surgery, as surgical antimicrobial prophylaxis. In situations where the incidence of MRSA-associated SSI is high or in case/s of penicillin allergy, vancomycin or fluoroquinolone can be used as an alternative. Current evidence supports the administration of an antimicrobial for surgical prophylaxis within 1 h before incision or before inflation of a tourniquet in orthopaedic procedures, or within 2 h for vancomycin or fluoroquinolones, because of their recommended infusion times [17, 18]. In most cases, it is recommended that a single dose of surgical antimicrobial prophylaxis is adequate.

1. Administration of prophylaxis antimicrobials should only be performed when indicated. (IA)
2. Prophylactic antimicrobials should be administered within 1 h before incision for all antimicrobials except vancomycin and fluoroquinolones where it should be administered within 2 h. (IA)
3. Re-dosing should be considered to maintain adequate tissue levels based on agent half-life. (IA)
4. A single dose of antimicrobial prophylactic is adequate for most surgical procedures. (IA)

Nutrition

Changes in host immunity may increase a patient’s susceptibility to SSIs and malnutrition may contribute to poor surgical outcomes, including delayed recovery, morbidity and mortality, prolonged hospital stay, increased health care costs and readmission. Meta-analysis and randomized controlled studies do not consistently show either benefit or harm when comparing standard versus enhanced nutritional support in reducing the risk of SSIs [19–22]. Underweight patients undergoing major surgical procedures, especially oncology and cardiovascular operations, however, may benefit from enhanced nutritional support.

1. Underweight patients undergoing major surgical procedures, especially oncology and cardiovascular operations, may benefit from the administration of oral or enteral multiple nutrient-enhanced nutritional formulas for the purpose of preventing SSI. (IIIC)

Glycemic control

One of the commonest surgical complications in patients with pre-existing diabetes mellitus and hyperglycemia is infection, with superficial surgical site infections (SSIs), deep wound infections, surgical space abscesses, urinary tract infections and pneumonia accounting for a large percentage of infectious complications. The American Diabetes Association defines poorly controlled diabetes as having a target HbA1c level of ≥8% [23]. Using this threshold, studies have shown a higher occurrence of postoperative wound infections in cardiac and orthopaedic patients who had HbA1C levels of ≥8% [24, 25]. To optimize the care of the patient with diabetes and reduce the risk of complications, a team-oriented approach to treatment is highly recommended [26–28].

1. Preoperative HbA1C levels should be less than 8%. (IIIC)

Normothermia

Exposure of large surfaces of skin to cold temperatures in the operating room can cause hypothermia. Hypothermia results in patients waking with chills and shivering, and also raises the risk for other complications such as SSI [29–32]. To avoid these complications, warming systems to transfer heat to a patient’s body are used. Several different methods are available, including a forced-air warming system, water bed system, and passive warming system such as blankets.

1. Maintain perioperative normothermia by using active warming devices. (IB)

Normovolemia

Hypovolemia and reduced cardiac output theoretically trigger musculocutaneous and splanchnic vasoconstriction, causing hypoperfusion and tissue hypoxia. Hemodynamic goal-directed therapy, a treatment based on the titration of fluid and inotropic drugs infused to physiologic flow-related end points, is shown to significantly reduce SSIs by 42% in a systematic review [33, 34].

1. Hemodynamic goal-directed therapy is recommended to reduce surgical site infection. (IA)

Irrigation

Wound irrigation is considered to be one of the most useful SSI prevention methods by many surgeons. We agree with WHO and NICE that there is inadequate evidence to comment on this and concur with WHO that antibiotic irrigation for SSI prevention should be avoided [35, 36].

1. There is insufficient evidence to recommend for or against saline of incisional wounds before closure for the purpose of preventing SSI. (IIC).

2. Avoid using antimicrobial agents to irrigate the incisional wounds before closure to reduce the risk of SSI. (IA).

Antimicrobial impregnated sutures

The latest meta-analysis by Leaper et al., focusing on the cost savings from SSI prevented with addition of antimicrobial sutures as a preventive measure (used in all classes of surgeries), suggests benefits [37].

1. Where there are high SSI rates in clean surgeries, in spite of basic preventive measures, individual centers may consider the use of antimicrobial impregnated sutures. (IIB)

Drapes

In various guidelines, it is generally accepted not to recommend non-iodine- impregnated adhesive incise drapes, since it is associated with SSI risk. However, in several observational studies especially in clean surgeries, marked SSI reduction reported with the proper use of iodine-impregnated drapes [38–42]. Considering the promising effect of controlling skin recolonization, and the fact that bacterial wound contamination may be directly linked to SSI, we believe that the use of iodine- impregnated adhesive incise drapes may be beneficial. Based on the above evidence, we do recommend their use when necessary, especially in orthopedic and cardiac surgeries.

1. When using adhesive incise drapes, do not use non-iodophor-impregnated drapes for surgery as they may increase the risk of surgical site infection. (IE).

2. In orthopedic and cardiac surgical procedures where adhesive incise drapes are used, consider using an iodophor-impregnated incise drape, unless the patient has an iodine allergy or other contraindication. (IIB).

Wound protectors

In the WHO Global Guidelines for the prevention of SSI, the expert panel concluded that the use of a wound-protector device (single-ring or double-ring) was associated with a significantly lower risk of SSI than with conventional wound protection (OR 0·42; 95% CI 0·28–0·62). Unfortunately, the quality of evidence was too low to justify a recommendation to routinely use wound protectors. In resource limited countries, these single use devices may be financially prohibitive [10, 43–45].

1. Careful evaluation of wound protectors needs to be done before introducing the use of wound protectors as a routine measure to reduce SSI. (IIIC)

Vancomycin powder

We concur with the Centers for Disease Control and Prevention (CDC), where in its latest guidelines strongly recommended not to apply antimicrobial agents (i.e. ointments, solutions, or powders) to the surgical incision for the prevention of SSI [46]. Though many studies provide supportive results, several serious concerns exist regarding their study designs, including the randomized controlled trials (RCTs) [47, 48]. With global concern on antimicrobial resistance, we will need to discourage the unnecessary resistance pressure associated with use, leading to vancomycin resistant Staphylococcus aureus (VRSA). Hence, vancomycin powder is not recommended for the purpose of preventing SSIs at this point, including spinal surgery.

1. Do not apply vancomycin powder into the surgical site for prevention of surgical site infection, including spine surgery. (IC)

Laminar air flow

Heterogeneity is seen with data published, and lack of standardization is noted in the surveillance methods and registers used regarding the use of laminar air flow and its association with SSI. In the latest meta-analysis from the WHO, with some additional studies, the risk for deep SSI in association with laminar air flow showed no significant difference compared with a conventional air flow system, with OR: 1.08(95% CI 0.77–1.52, p = 0.65) for knee arthroplasty, OR: 1.29 (95% CI 0.98–1.71, p = 0.07) for hip arthroplasty, and OR: 0.75(95% CI 0.43–1.33, p = 0.33) for abdominal and open vascular surgeries. Therefore, WHO has suggested laminar air flow is not required to reduce the risk of SSI for patients undergoing total arthroplasty surgery, and laminar air flow is not required in new operating rooms. Due to the high expense, laminar air flow is not considered necessary for installation in new operating rooms, unless supportive sufficient clinical evidence has been provided.

1. Installation of laminar airflow is not required in new or renovated operating rooms to prevent SSIs. (IIC)